Palo Santo, literally meaning “holy wood” in Spanish, is a tree that is widely distributed throughout Central and South America. Palo Santo is used in South America in much the same way white sage is used in North America- to combat negative energy and to cleanse the space. For thousands of years, the wood, resin, and oil of palo santo have been used for medicinal purposes. It’s mainly used to treat pain and stress. It’s also said to clear negative energy.